Successful Treatment of Severe Adenoviral ARDS Using Cidofovir in a Case with Cerebral Palsy
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    Case Report
    P: 50-53
    April 2021

    Successful Treatment of Severe Adenoviral ARDS Using Cidofovir in a Case with Cerebral Palsy

    J Pediatr Emerg Intensive Care Med 2021;8(1):50-53
    1. Ankara Üniversitesi Tıp Fakültesi, Çocuk Yoğun Bakım Bilim Dalı, Ankara, Türkiye
    2. Ankara Üniversitesi Tıp Fakültesi, Çocuk Enfeksiyonları Hastalıkları Bilim Dalı, Ankara, Türkiye
    No information available.
    No information available
    Received Date: 07.08.2019
    Accepted Date: 30.12.2019
    Publish Date: 25.03.2021
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    ABSTRACT

    Adenovirus is a non-enveloped, double-stranded DNA virus that can cause infections in the upper and lower respiratory tract, conjunctiva, and gastrointestinal tract. Adenovirus infections are usually mild but may cause mortality and morbidity, especially in immunocompromised patients. Cidofovir may be used to treat adenovirus. Cidofovir is an antiviral with a virostatic effect, especially effective for adenovirus and herpes virus. In this case report, we present a 15-year-old patient with adenovirus-induced severe acute respiratory distress syndrome, who was referred to us for renal failure and successfully treated with cidofovir.

    Keywords: Adenovirus, cidofovir, child, pediatric respiratory distress syndrome, pneumonia

    References

    1
    Yoon HY, Cho HH, Ryu YJ. Adenovirus pneumonia treated with Cidofovir in an immunocompetent high school senior. Respir Med Case Rep. 2019;26:215-8. 
    2
    Li L, Woo YY, de Bruyne JA, Nathan AM, Kee SY, et al. Epidemiology, clinical presentation and respiratory sequelae of adenovirus pneumonia in children in Kuala Lumpur, Malaysia. PLoS One. 2018;13:0205795. 
    3
    Xie L, Zhang B, Zhou J, Huang H, Zeng S, et al. Human adenovirus load in respiratory tract secretions are predictors for disease severity in children with human adenovirus pneumonia. Virol J. 2018;15:123.
    4
    Ions R, Narayanan M, Browning M, Gaillard EA, Stiefel G, et al. Case presentation: persistent adenovirus B3 infections associated with bronchiolitis obliterans treated with cidofovir in a child with mosaic tetrasomy 9p. BMC Infect Dis. 2018;18:529. 
    5
    Gavin PJ, Katz BZ. Intravenous ribavirin treatment for severe adenovirus disease in immunocompromised children. Pediatrics. 2002;110:9.
    6
    Muller MP, Siddiqui N, Ivancic R, Wong D. Adenovirus-related epidemic keratoconjunctivitis outbreak at a hospital-affiliated ophthalmology clinic. Am J Infect Control. 2018;46:581-3. 
    7
    Vora SB, Brothers AW, Englund JA. Renal Toxicity in Pediatric Patients Receiving Cidofovir for the Treatment of Adenovirus Infection. J Pediatric Infect Dis Soc. 2017;6:399-402.
    8
    Caruso Brown AE, Cohen MN, Tong S, Braverman RS, Rooney JF, et al. Pharmacokinetics and safety of intravenous cidofovir for life-threatening viral infections in pediatric hematopoietic stem cell transplant recipients. Antimicrob Agents Chemother. 2015;59:3718-25. 
    9
    Hoffman JA, Shah AJ, Ross LA, Kapoor N. Adenoviral infections and a prospective trial of cidofovir in pediatric hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2001;7:388-94. 
    10
    Kim SJ, Kim K, Park SB, Hong DJ, Jhun BW. Outcomes of early administration of cidofovir in non-immunocompromised patients with severe adenovirus pneumonia. PLoS One. 2015;10:0122642.
    11
    Alcamo AM, Pinchasik DE, Mo JQ, Grimley MS, O’Brien MM. Successful Treatment of Disseminated Adenovirus Infection in an Infant With Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2015;37:178-81.
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